Motion compatible sensor for non-invasive optical blood analysis

ABSTRACT

A non-invasive optical sensor which uses the motion signal to calculate the physiological characteristic being measured. For pulse oximetry, a least squares or a ratio-of-ratios technique can be applied to the motion signal itself. This is made possible by selecting a site on the patient where variations in motion produce signals of two wavelengths which are sufficiently correlated. In particular, it has been determined that a sensor placed on a nail, in particular a thumbnail, exhibits the characteristics of having the red and infrared signals correlated when used for pulse oximetry, and the resulting signals correlate to arterial oxygen saturation.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a divisional of U.S. application Ser. No.09/348,437, filed Jul. 7, 1999, now U.S. Pat. No. 6,374,129, which is adivisional of U.S. application Ser. No. 08/722,443, filed Oct. 10, 1996,now U.S. Pat. No. 6,018,673, the disclosures of which are incorporatedby reference.

BACKGROUND OF THE INVENTION

The present invention relates to optical sensors for non-invasivedetermination of physiological characteristics, and in particular tosensors for making such determinations in the presence of motion.

Many types of optical sensors are used to measure physiologicalcharacteristics of a patient. Typically, an optical sensor providesemitted light which is then scattered through tissue and detected.Various characteristics of a patient can be determined from analyzingsuch light, such as oxygen saturation, pulse rate, pH, etc.

Pulse oximetry is typically used to measure various bloodcharacteristics including, but not limited to, the blood-oxygensaturation of hemoglobin in arterial blood, the volume of individualblood pulsations supplying the tissue, and the rate of blood pulsationscorresponding to each heartbeat of a patient. Measurement of thesecharacteristics has been accomplished by use of a non-invasive sensorwhich scatters light through a portion of the patient's tissue whereblood perfuses the tissue, and photoelectrically senses the absorptionof light in such tissue. The amount of light absorbed is then used tocalculate the amount of blood constituent being measured.

The light scattered through the tissue is selected to be of one or morewavelengths that are absorbed by the blood in an amount representativeof the amount of the blood constituent present in the blood. The amountof transmitted light scattered through the tissue will vary inaccordance with the changing amount of blood constituent in the tissueand the related light absorption. For measuring blood oxygen level, suchsensors have typically been provided with a light source that is adaptedto generate light of at least two different wavelengths, and withphotodetectors sensitive to both of those wavelengths, in accordancewith known techniques for measuring blood oxygen saturation.

Known non-invasive sensors include devices that are secured to a portionof the body, such as a finger, an ear or the scalp. In animals andhumans, the tissue of these body portions is perfused with blood and thetissue surface is readily accessible to the sensor. A photoelectricpulse transducer from World Precision Instruments is described as evenrecording signals through the fingernail.

Optical sensors are typically either reflective or transmissive.Transmissive sensors have the emitter and detector on opposite sides ofa finger, toe, nose or other tissue. They measure light transmittedthrough the tissue from one side to the other. Reflectance sensors, onthe other hand, have the emitter and detector side-by-side, such asplacement on the forehead, or on a fetus where it is difficult toposition a sensor over a finger, etc. Reflectance sensors detect lightwhich is scattered back to the same surface.

In pulse oximetry, the goal is to determine the amount of oxygen inarterial blood, as distinguished from venous blood or the tissue itself.The light emitted can be absorbed by all three, however, and they needto be distinguished among. FIG. 1 illustrates a plot of the logarithm ofthe detected intensity signal versus time. Solid line 10 is the detectedinfrared signal in a pulse oximeter, shown varying with time. Dottedline 12 is the detected red wavelength signal. As can be seen, the valuemoves up and down with the heartbeat frequency, due to the pulsing ofthe blood through the arteries. The portion of the signal below line 14is representative of light absorbed by the tissue, venous blood, and abaseline component of the arterial blood.

Using appropriate signal analysis, the DC portion can be eliminated,leaving an extracted AC portion which is due to absorption by arterialblood. As can be seen in FIG. 1, and more clearly in FIG. 2, the red andinfrared signals, although varying by different amounts, are in phase.FIG. 2 illustrates a plot over an epoch of time of the red logarithmicsignal versus the infrared logarithmic signal, and is commonly referredto as a Lissajous plot. As can be seen, a line is formed, indicatingthey are in phase.

This characteristic of the red and infrared signals allows thedetermination of oxygen saturation through two methods. In a firstmethod, the “ratio of ratios” is calculated, which is the ratio, betweenred and infrared, of the logarithms of the quotients obtained bydividing the maximum signal intensity and the subsequent minimum signalintensity. This ratio-of-ratios is then used in a predetermined formulato calculate arterial oxygen saturation. This is described more fully inU.S. Pat. No. 4,653,498.

In a second method, referred to here as “least squares,” a least squaresregression analysis is performed on the above-mentioned Lissajous plotto determine the slope of the ensemble of data points taken during anepoch of time. This slope is then used in a predetermined formula todetermine arterial oxygen saturation. Other techniques are set forth ina copending application entitled “Method and Apparatus for EstimatingPhysiological Parameters Using Model-Based Adaptive filtering,” filedJun. 7, 1996, Ser. no. 08/660,510, the disclosure of which is herebyincorporated by reference.

In some cases, it is desirable to measure the oxygen saturation of thevenous blood in order to get an indication of how much oxygen is beingused by the body. The arterial blood, on the other hand, gives anindication of how much oxygen is being delivered to the body. In ShigaU.S. Pat. No. 4,927,264, the oxygen saturation in venous blood isdetermined by inducing a venous pressure with a pressure cuff. Thiseffectively varies line 14 of FIG. 1 at a frequency different from theheart rate, so that it can be separately filtered and isolated andcompared to the arterial pulse. The nonvarying portion is then assumedto be the tissue absorption and can be distinguished from the slowlyvarying pressure induced venous blood absorption. An alternate approachcan be used in extracorporeal monitoring where the blood is actuallypumped out of the body and then back in. Such a technique is set forthin an article by Odell et al., entitled “Use of Pulse Oximetry toMonitor Venous Saturation During Extracorporeal Life Support” CriticalCare Medicine, vol. 22, no. 4 (Apr. 4, 1994). In Odell, the venous bloodbeing pumped out of the body passes the sensor, and the pumpingmechanism provides an artificial pulse allowing the use of pulseoximetry techniques.

Motion artifact can degrade a pulse oximetry signal relied upon by aphysician, without the physician's awareness. This is especially true ifthe monitoring of the patient is remote, the motion is too small to beobserved, or the doctor is watching the instrument or other parts of thepatient, and not the sensor site. Thus, typically techniques areemployed to reduce the effects of motion or compensate for motion.

In one oximeter system described in U.S. Pat. No. 5,025,791, anaccelerometer is used to detect motion. When motion is detected,readings influenced by motion are either eliminated or indicated asbeing corrupted. In a typical oximeter, measurements taken at the peaksand valleys of the blood pulse signal are used to calculate the desiredcharacteristic. Motion can cause a false signal peak and valley,resulting in a measurement having an inaccurate value and one which isrecorded at the wrong time. In U.S. Pat. No. 4,802,486, assigned toNellcor Puritan Bennett, the assignee of the present invention, an EKGsignal is monitored and correlated to the oximeter reading to providesynchronization to limit the effect of noise and motion artifact pulseson the oximeter readings. This reduces the chances of the oximeterlocking onto a periodic motion signal. Still other systems, such as theone described in U.S. Pat. No. 5,078,136, assigned to Nellcor PuritanBennett, use signal processing in an attempt to limit the effect ofnoise and motion artifact. The '136 patent, for instance, uses linearinterpolation and rate of change techniques to analyze the oximetersignal. U.S. Pat. No. 5,337,744 sets forth sensor modifications used toimprove the immunity of the signal from motion artifacts.

The motion signal impedes the measurement because it obscures thecardiac signal. The motion signal can have many components, such as, forexample, the emitter or detector physically moving away from the body,or a volume of venous and arterial blood sloshing around in response tothe motion, or the signal path being shortened or lengthened byexpansion or compression of the tissue due to motion.

Contrary to conventional practice, signal analysis might be able todirectly use the time-varying motion signal to calculate oxygensaturation. Under some conditions, the ratio-of-ratios (or leastsquares) resulting from a motion-induced signal has the same value asthe ratio-of-ratios (or least squares) for the cardiac induced signal.The red and infrared intensity signals are often not in phase, and canlimit the use of the motion signal for calculating oxygen saturation.One of the factors that may cause this is illustrated in FIG. 3. As FIG.3 illustrates, light from emitter 28 can pass through skin 13, fat 15,muscle 16, and bone 18, on its way to a detector 30. Light of onewavelength may, on average, take path 32, while light of anotherwavelength may penetrate deeper and take path 34. Motion will causedisproportionate variances in the path lengths of the two wavelengths oflight, resulting in out-of-phase signals of the detector.

SUMMARY OF THE INVENTION

The present invention provides a non-invasive optical sensor which usesthe motion signal to calculate the physiological characteristic beingmeasured. For pulse oximetry, a least squares or a ratio-of-ratiostechnique can be applied to the slope of the motion signal itself. Thisis made possible by selecting a site on the patient where motionproduces signals at two wavelengths which are adequately correlated witheach other. Adequately correlated signals have a “closed” or “nearlyclosed” Lissajous. In particular, it has been determined that a sensorplaced on a nail, in particular a thumbnail, exhibits thecharacteristics of having the red and infrared signals in phase whenused for pulse oximetry.

The present invention also provides an optical sensor which fitsentirely on a nail. No adhesive or other securing mechanism around therest of the finger is necessary, resulting in the entire sensor movingwith the nail. The use of the nail site reduces the likelihood ofout-of-phase motion signals for red and infrared wavelengths, and takesadvantage of the predominantly arterial blood saturation characteristicof the blood present beneath the nail. In addition, the nail is anadvantageous surface for adhering the sensor to, and at this locationthe method of attachment allows a low profile, low mass sensor to beused which further limits differential phase errors due to motion.

Preferably, the sensor on a nail of the present invention is areflectance-type sensor. In one embodiment, a closer spacing is usedthan in typical prior art sensors, preferably less than 5 mm., morepreferably approximately 4 mm. It has been empirically determined thatthe physiological characteristics at a nail site produce an improvedsignal with closer spacing. In addition, the sensor preferably has acurvature which conforms to the shape of the nail, and is attached withan adhesive.

In alternate embodiments of the invention, artificial motion may beinduced with an air bag or otherwise to produce a motion signal whichcan be used with the sensor of the invention. In particular, this couldbe used for patients with low perfusion, a weak heartbeat or noheartbeat such as is the case during heart bypass surgery.

For a further understanding of the nature and advantages of theinvention, reference should be made to the following description takenin conjunction with the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a graph of the log of the infrared and red intensity signalsfor pulse oximeters.

FIG. 2 is a graph of the red and IR signals showing correlation.

FIG. 3 is a diagram of the different average paths of differentwavelength light through a patient.

FIG. 4 is a perspective view of a nail sensor according to the presentinvention on a thumb.

FIG. 5 is a cross-sectional, cutaway view of a thumb showing itscomponents.

FIG. 6 is a end, cutaway view of one embodiment of a conformable nailsensor according to the present invention.

FIG. 7 is a diagram of a sensor according to the present inventionplaced longitudinally to span the lunula of the nail.

FIGS. 8A-8D are Lissajous plots of the output of a sensor according tothe invention with and without motion, and at low and high saturation.

FIG. 9A is a plot of the red and infrared frequency distribution (FFT oftime signals) showing experimental results from a thumbnail sensoraccording to the invention.

FIG. 9B is a plot of the Lissajous for the results of FIG. 9A.

FIG. 10 is a graph showing a plot of oxygen saturation readings of asensor according to the present invention compared to a standard priorart sensor.

FIGS. 11A and 11B compare the prior art sensor and the presentinvention. The output waveforms and Lissajous plot are shown for each.

FIG. 12 is a diagram of an alternate embodiment of the invention showinga combination reflective and transmissive sensor.

FIG. 13 is a diagram of an alternate embodiment of the invention showinga self-contained nail sensor with its own display.

FIG. 14 is a diagram of a nail sensor with a motion inducing mechanismaccording to the present invention.

FIGS. 15 and 16 are top and side views of the motion stimulatingmechanism of FIG. 14.

FIG. 17 is a flowchart of one embodiment of a program for responding towhether motion or a cardiac pulse is used for calculating saturation.

FIG. 18 is a block diagram of one embodiment of portions of an oximeterusing controlled generation of motion.

FIG. 19 is a diagram of an embodiment of the sensor using a cylindricallens and a tinted adhesive.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

FIG. 4 illustrates a sensor 40 according to the present inventionpreferably mounted on a nail 42 (a thumbnail or any other digit may beused). The sensor is held on with adhesive, and has an emitter 44 and adetector 46. A flexible circuit 48 provides the electrical connectionsto the emitter and detector, and may be accordion-shaped between thesensor and a securing band 50 to provide additional strain relief. Thisisolates the sensor from tugging or pulling on the electrical connectioncord from either the sensor side or the other direction. Band 50 may be,for instance, an elastic band, cloth wrap secured with Velcro™, oranother device. Flexible circuit 48 could be electrical wires or fiberoptic cables. The different wavelength light could be premixed using thefiber optic cable.

The placement on the top of the nail allows the cable to extend alongthe top of the finger or other digit, without the sensor or the cablebeing on the palmar side of the digit where it would interfere withgrasping or other functionality of the hand.

As can be seen, the emitter 44 and detector 46 are arranged laterallyacross the width of the nail. However, a longitudinal arrangement(discussed more fully below) or any other arrangement on a nail ispossible. The spacing of the emitter and detector may be varied, but anoptimum spacing was experimentally found to be less than 10 mm.,preferably less than 5 mm., more preferably approximately 4 mm.

The nailbed makes a good site for the sensor because it has beenobserved that motion generates artifact signals for the red and infraredwavelengths that are largely correlated to one another. The inventorshave observed that this results in a ratio-of-ratios (or least squares)which correlates well with the arterial oxygen saturation.

Referring to FIG. 5, a cross-sectional view of the thumb is shown. Ascan be seen, the thumb includes a bone 52 with a thin layer ofconnective tissue 54 between the bone and thumbnail 56. A number ofcharacteristics may contribute to the improved signal and the motioninduced artifact being in phase. The different wavelength pathsillustrated in FIG. 3 may be limited by the presence of bone 52,preventing one of the wavelengths from going deeper into tissue andhaving a different distance to travel. This effect is provided by theselection of the thumbnail as a site, and the use of reflectanceoximeter sensor as opposed to a transmissive sensor. In a transmissivesensor, light would have to travel around the bone deep through thetissue, and the red and infrared may travel different lengths and beaffected differently by motion.

Connective tissue layer 54 is thin and apparently strongly connective.Thus, the expansion and compression of tissues, particularly fattytissues, which may cause out of phase motion artifacts for other sitesand types of sensors, is apparently greatly reduced here. Because thethumbnail 56 itself provides a strong mounting platform, the sensor canbe securely attached to it with adhesive, avoiding the emitter anddetector from separating from the patient and causing gaps that maycause corrupt ratio-of-ratio values.

The region beneath nail 56 also provides a region which appears to beconcentrated with oxygen saturated blood similar to the saturation ofarterial blood. Oxygen consumption beneath the nail appears to be smallrelative to the circulation there, or the relative volume of venousblood may be negligibly small.

The presence of many small capillaries, rather than large vessels, makesthe region more homogeneous, and thus lessens the likelihood that twodifferent light wavelengths would be affected differently by passingthrough differing regions. In the absence of motion, the high perfusionallows a normal pulse oximetry reading to be made. During the occurrenceof motion, the large amount of blood present allows a strong motionsignal to be obtained, since a lot of blood is moved around by themotion. In experiments conducted by the inventors, motion artifactsignals greater than 50 times that of a normal pulsatile plethysmogramsignal have been observed. The nail site also appears to have anailbed-tissue boundary that is optically phase-matched for thewavelengths of the sensor.

In addition to measuring oxygen saturation, the nailbed is a good sitefor other optical sensors. For example, glucose detection which requiresthe use of a near infrared wavelength could be used. Among the bloodproperties or constituents that can be measured are blood gases (CO₂,O₂) pH, glucose, drug concentrations, or other analytes (THb, Hct,lactate, K⁺, Na⁺, Ca²⁺, etc.).

FIG. 6 is an end, cutaway view of one embodiment of a sensor 40according to the present invention. Emitter 44 and detector 46 are shownmounted on a flexible circuit board 60. An electrical cord 62 providesthe connection to the electrical components of circuit board 60. Thebody of the sensor is preferably a semi-rigid piece of black poron foam.A metal strip could be imbedded to give extra rigidity. An adhesive isattached to underside 64 of the sensor to attach it securely to thenail. The underside is also curved to conform to the shape of the nail,but is slightly flexible to allow adaptation to differing nail shapes.Different curvature sensors could be provided for different sizes andshapes of nails to provide optimum fit, or the bottom surface could befabricated from a softer, more conforming material.

One characteristic of the nail as a site is that the nail itself couldact as a light pipe, shunting light between the emitter and thedetector. Preferably, the light travels through the tissue beneath thenail along a path 66. However, some light could bounce back and forththrough the nail itself on a path 68 between the emitter and detector ina manner not unlike a waveguide. To limit this shunting, the sensor bodyis made to absorb light, or at least the region between the emitter anddetector is made at least partially absorbing to the wavelengths ofinterest. In this way, each time light strikes the side of the nailadjacent the absorbing layer, it will be absorbed, rather thanpropagating along the nail.

Shunting can also be limited by recessing the emitter and detector andproviding a narrow numerical aperture. Because of the rigidity of thesensor body, recessing will not produce variations in distance duringmotion. By limiting the numerical aperture of the emitter and detectorto values less than 0.9., preferably to values less than 0.5, theemitter will not directly launch light into the nail “waveguide,” andlight which does potentially travel path 68 will be outside theacceptance angle of the detector.

The nail also provides advantages for adhering the sensor to the patientsince the nail does not have the quantity of oils or sweat as present onthe skin.

FIG. 7 is a diagram of a sensor 700 arranged longitudinally along a nail706. The sensor has an emitter 702 and a detector 704 which are not bothon the lunula of the nail. The lunula is the light colored area of thenail below line 708 in FIG. 7. It is believed that if both the emitterand detector are located on the lunula, more undesirable shunting oflight will occur.

FIG. 8 has FIGS. 8A-8D which show the Lissajous plots and calculatedsaturations for a sensor according to the present invention during fourconditions: motion and no motion at high and low saturation. As can beseen in FIGS. 8A and 8B at high saturation, the calculated saturation100% is equivalent with or without motion. In FIG. 8B, the motion signalis seen to be more than 10 times larger than the cardiac signal of FIG.8A (FIGS. 8A and 8C are magnified by 10). Similar results occur at lowsaturation as seen in FIGS. 8C and 8D where the saturation values arecalculated to be 70% under both conditions.

FIG. 9A is a graph of the frequency distribution of the detected red andinfrared signals for a sensor of the present invention in an experimentwith an 8 Hz artificial motion pulse applied. The cardiac signature canbe seen at the lower frequencies below 5 Hz, while the 8 Hz drivenmotion signal is also visible. FIG. 9B is a graph of the red versusinfrared intensity signals for the experiment illustrating that bothsignals are correlated and representative of the same saturation.

FIG. 10 illustrates the oxygen saturation readings of a sensor accordingto the present invention in experimental tests without motion comparingit with a standard prior art transmissive sensor at another site. Aclose agreement was noted, indicating the calibration of this sensor onthe nailbed site is similar to a conventional transmission sensor.

FIGS. 11A and 11B show a comparison of the output waveform andLissajous, in the presence of motion, of a sensor according to thepresent invention (FIG. 11B) with a standard prior art transmissivesensor at another site (FIG. 11A).

FIG. 12 illustrates an alternate embodiment of the present invention inwhich a nail sensor 70 according to the present invention is attachedvia a flexible circuit 72 to a transmissive sensor 74 which wraps aroundthe finger and has an emitter 76 and detector 78 positioned on top andon the bottom of the finger. Such a combination sensor could allow theoximeter monitor with its program to choose between the sensorsdepending upon motion conditions. When motion is present, nail sensor 70could be used, and when motion is not present, sensor 74, which may bemore sensitive to the cardiac pulse signal, could be used. Alternately,a single pair of red and infrared emitters could be used, with areflectance detector on the nail, and a transmissive detector off thenail. Depending on the mode, a switch in the sensor, or in anintermediate amplifier module, or in the oximeter monitor could selectbetween the detectors. In another embodiment, a single detector is used,with one pair of emitters on the nail, and another pair of emitters offthe nail. Alternately, a completely separate transmissive sensor couldbe used.

In some patients, in particular those with low blood perfusion, it maybe difficult to lock onto a pulse waveform. The additional transmissivesensor could be used to enable locking on for such patients. Inaddition, a transmissive sensor could be used to calibrate the nailsensor “on-the-fly.” Because of shunting and other unique aspects of thenail site, a predetermined calibration may be off. A measurement ofsaturation using the transmissive and the nail reflectance sensors couldbe done in the absence of motion, with a correction factor applied tothe reflectance sensor. The correction could be a constant which isadded or a multiplicative factor, or both. If measurements are done atdifferent saturations, a calibration line or curve could be determinedby the oximeter to allow adjustments anywhere along the calculatedcurve. Subsequently, in the presence of motion, the nail sensor will bemore accurately calibrated.

FIG. 13 illustrates an alternate embodiment of the invention in which aself-contained sensor 80 according to the present invention includes theprocessing circuitry on one or more semiconductor chips inside, and hasits own display 82, which may be a liquid crystal display, for instance.In one embodiment, a button 84 allows switching between modes, such asbetween displaying a pulse and oxygen saturation. In an alternateembodiment, a flex connection 86 to a module 88 attached on a band 90may be used. Module 88 might contain the battery, or alternately theprocessing circuitry, or the display. Additionally, either embodimentcould be used for a wireless transmission to an oximeter, with thetransmitting circuit either being in module 88 or sensor body 80.

FIG. 14 illustrates another embodiment of the present invention in whicha stimulator is used to generate an artificial pulse. A stimulator couldelectrically stimulate the nerves to cause motion of an appendage, orcould use a pneumatic pressure cuff to stimulate an artificial pulse, oruse electro-mechanical stimulation or any other mechanism whichgenerates a pulse characteristically different (e.g., amplitude,frequency, shape, etc.) than the cardiac pulse so that the cardiac pulseneed not be used. Such an apparatus would be particularly advantageousfor patients with low blood perfusion or a weak heartbeat. FIG. 14 isone embodiment showing a sensor 92 mounted on a thumbnail, with anairbag 94 mounted to the bottom of the thumb and held in place with aband 96. A hose 98 to the airbag periodically inflates and deflates it,causing a pressure wave through the thumb, giving artificially inducedmotion. This pressure induced motion provides the variation needed forsensor 92 to measure the oxygen saturation using either theratio-of-ratios or a least squares technique. If the motion is in thefrequency range of a heartbeat, the sensor can be backward compatiblewith existing oximeter monitors, even those that look for a cardiacsignal.

FIG. 15 illustrates airbag 94 in a top view, showing hose 98 connectedto a diaphragm pump 100. FIG. 16 shows a side view of the airbag 94 ofFIG. 15, showing that it is wide but flat.

FIG. 17 is a flowchart of one embodiment of a portion of a program foroperating an oximeter so that either cardiac pulses or motion pulses canbe used to calculate oxygen saturation. The oxygen saturation iscalculated in a known manner (step A). In a first alternative, thesignal is analyzed to determine if it is a cardiac pulse or a motionpulse (step B). This can be done using any of the pulse qualification ormotion detection techniques known to those of skill in the art. If amotion signal is present and used for the oxygen saturation calculation,then in step C only the oxygen saturation signal is displayed, and not apulse rate (which would be a motion pulse rate, and not the patient'sheart rate). If a cardiac pulse is used, the pulse rate is alsodisplayed (step D).

Alternately, a pulse determination step E could be used where the sensorincludes both a reflectance sensor and a transmittance sensor. If motionis present above a predetermined threshold (such as at least twice thearterial pulse signal), the reflectance sensor is used, which uses themotion signal, and alters any motion filtering or motion reductiontechniques (step F). If the motion signal is below the threshold, thetransmittance sensor is used (step G), with standard motion reductiontechniques being employed (either hardware or software or both).

Both sensors could be energized in an ongoing manner, and the saturationand rate could be chosen to come from the sensor considered mostreliable, depending on the instrument's assessment of motion.Simultaneous computation may further allow improved processed signalestimates of cardiac rate in the presence of motion given knowledge ofestimated saturation.

FIG. 18 is a block diagram of a portion of a pulse oximeter monitor usedin conjunction with an artificial pulse generator, such as shown inFIGS. 14-16. A frequency generator 110 produces a desired frequency forthe motion pulse. This could be varied to give a frequency which is notinterfered with by other noise, or frequency hopping could be used toisolate the signal from other sources of motion or noise. A pumpcontroller 112 activates a pump or motor 100 (FIG. 12) at the generatedfrequency. Since the driven frequency is known, optionally otherfrequencies could be filtered out to reduce noise. After a signal iscaptured and converted to digital form by a circuit 114, a bandpassfilter 116 is used to reduce other frequency signals. A control signalfrom frequency generator 110 could vary the bandpass frequency. Acircuit or processor 118 then calculates the oxygen saturation. Acentral controller 120 controls the rest of the circuitry, including asensor driver circuit 122, which could selectively activate differentreflectance and transmittance emitters in one embodiment. Controller 120could also analyze the signals for the presence of motion to alternatebetween motion and cardiac pulse modes in one embodiment. Alternately, aseparate motion sensor could provide an input to controller 120. Notethat other physical implementations are possible, such as using a singleprocessor to do the filtering, the frequency generation and the oxygensaturation calculation.

A calibration resistor (or other active or passive element) 115 encodesthe mean wavelength of at least one LED, and provides it to acalibration reader circuit or CPU 120. The wavelength indicated is usedto select coefficients stored in the monitor. Such a calibrationtechnique is described in more detail in U.S. Pat. No. 4,621,643, thedisclosure of which is incorporated herein by reference.

FIG. 19 is a cut-away view of an embodiment of a sensor 130 according tothe invention. An emitter 132 is mounted on a circuit 134 inside thesensor housing. A cylindrical lens 136 is mounted in an aperture 138.The lens directs the light down through the nail, minimizing the lightwhich hits the nail at an angle and can be shunted to the detector. Anaperture itself can perform the same function, but the lens insures thatmore of the light is used, maintaining a higher intensity at a givenpower, or allowing less power to be used. Detector 140 is recessed in aaperture 142 to avoid shunted light on the receiving end.

The sensor is secured to a nail 144 using an adhesive layer 146. Theadhesive layer can act as a shunt path itself. Accordingly, the adhesivelayer may be tinted to be opaque to the wavelengths used, withpreferably transparent windows 148 and 150 for the detector and emitterapertures.

As will be understood by those of skill in the art, the presentinvention could be embodied in other specific forms without departingfrom the spirit or essential characteristics thereof. For example, asensor could be placed on a fingernail other than the thumb nail, andcould be placed on toenails. Alternately, a sensor could be placed onthe cuticle or the live nail fold skin extending over the beginning ofthe nail. The sensor could be attached with a clip-type sensor, or anelastic wrap, bandage or adhesive which encircles the appendage could beused. The sensor could be placed at locations other than the nailbedwhere signals at the multiple wavelengths in the presence of motion arestill adequately correlated. The emitter in the sensor could befabricated using an optical fiber to carry the light from a sourceremotely located, and equivalently the detector could be an opticallight guide to pipe the light to a remote detector. Accordingly,reference should be made to the following claims which set forth thescope of the invention.

1. A photometric device for processing detector signals representativeof a blood property of a patient from a sensor attached to said patient,said sensor including a radiation emitter and a radiation detector, saidmonitor comprising: a control unit configured to generate an activationsignal to selectively activate said emitter; and a processing unitconfigured to receive said detector signals and to process said detectorsignals utilizing at least two points on a motion signal that is part ofsaid detector signal waveform produced by motion of said patient, aslope of said motion signal being used in an algorithm to calculate saidblood property.